DHEA is a natural steroid made from cholesterol primarily by the adrenal glands. Studies show that DHEA may help with systemic lupus, and may decrease cholesterol. In long term studies, it reduced insulin resistance and also helped relieve depression.

DHEA functions to boost the immune system in auto-immune disease. It is contraindicated in patients that have testosterone or estrogen related cancer.

A low DHEA level may be an indication of adrenal fatigue.

DHEA supplementation must be tested on a regular schedule as it may, in men, convert to estrogen. Although readily available over the counter in health food stores, it is a powerful hormone that should be monitored.